EFFECTS OF DEPRESSION ON IMMUNE SYSTEM AMONG OLD PEOPLE IN BENGALURU, INDIA
Abstract
Purpose of the Study: The study aimed to examine the effects of depression on immune system among old people in Bengaluru, India
Statement of the Problem: The impact of depression on the immune system among older adults in Bengaluru, India, remains a significant concern that requires further examination. Limited research focusing on this specific population hinders a comprehensive understanding of the mechanisms underlying the relationship between depression and immune function in older adults living in Bengaluru. Addressing this gap in knowledge is essential to develop targeted interventions and improve the overall well-being and immune health of older adults in the city.
Methodology: Desk study review methodology was used for the paper where relevant empirical literature was reviewed to identify main themes. A very thorough review of empirical literature took place to expound on the effects of depression on immune system among old people in Bengaluru, India Findings.
Findings: Older adults in Bengaluru, India, experiencing depression showed elevated levels of stress hormones, particularly cortisol, indicating chronic stress as a potential mechanism influencing the immune system. Depression was associated with increased inflammation markers, such as C-reactive protein (CRP) and interleukin-6 (IL-6), suggesting a relationship between depression and immune activation, which may compromise immune response. Sleep disturbances were prevalent among older adults with depression, potentially exacerbating immune dysregulation and making them more susceptible to infections and diseases.
Conclusion: Elevated stress hormones, increased inflammation, and prevalent sleep disturbances observed in participants with depression suggest that mental health plays a crucial role in influencing immune function in this vulnerable population. Addressing depression and its effects on immune health is imperative to improve the overall well-being and resilience of older adults in Bengaluru, promoting better health outcomes and quality of life in this growing demographic.
Recommendations: Enhance mental health awareness and destigmatize depression among older adults in Bengaluru, India. Public health campaigns and community-based initiatives should be employed to promote understanding and acceptance of mental health issues, encouraging individuals to seek timely support and treatment. Integrate mental health screening and support into primary healthcare settings for older adults. Regular screenings for depression can aid in early detection and intervention, enabling healthcare professionals to provide appropriate mental health support and improve immune system outcomes. Develop targeted interventions to address stress reduction and coping strategies for older adults with depression in Bengaluru. Stress management programs, mindfulness practices, and social support networks can help reduce the impact of depression on the immune system, fostering better overall well-being and health outcomes in this population.
Keywords: Depression, Immune System, Old People, India
References
Barbé-Tuana, F., Funchal, G., Schmitz, C. R. R., Maurmann, R. M., & Bauer, M. E. (2020, October). The interplay between immunosenescence and age-related diseases. In Seminars in immunopathology (Vol. 42, pp. 545-557). Springer Berlin Heidelberg.
Bastiaanssen, T. F., Cussotto, S., Claesson, M. J., Clarke, G., Dinan, T. G., & Cryan, J. F. (2020). Gutted! Unraveling the role of the microbiome in major depressive disorder. Harvard Review of Psychiatry, 28(1), 26.
Bhandari, P., & Paswan, B. (2021). Lifestyle behaviours and mental health outcomes of elderly: Modification of socio-economic and physical health effects. Ageing International, 46, 35-69.
Cañas-González, B., Fernández-Nistal, A., Ramírez, J. M., & Martínez-Fernández, V. (2020). Influence of stress and depression on the immune system in patients evaluated in an anti-aging unit. Frontiers in psychology, 11, 1844.
Hayley, S., Hakim, A. M., & Albert, P. R. (2021). Depression, dementia and immune dysregulation. Brain, 144(3), 746-760.
Hwang, I. Y., Choi, D., Kim, J. A., Choi, S., Chang, J., Goo, A. J., ... & Park, S. M. (2022). Association of short-term particulate matter exposure with suicide death among major depressive disorder patients: a time-stratified case-crossover analysis. Scientific reports, 12(1), 8471.
Keyes, K. M., Gary, D., O’Malley, P. M., Hamilton, A., & Schulenberg, J. (2019). Recent increases in depressive symptoms among US adolescents: trends from 1991 to 2018. Social psychiatry and psychiatric epidemiology, 54, 987-996.
Koenig, L. R., Blum, R. W., Shervington, D., Green, J., Li, M., Tabana, H., & Moreau, C. (2021). Unequal gender norms are related to symptoms of depression among young adolescents: a cross-sectional, cross-cultural study. Journal of Adolescent Health, 69(1), S47-S55.
Mattina, G. F., Van Lieshout, R. J., & Steiner, M. (2019). Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events. Therapeutic advances in cardiovascular disease, 13, 1753944719851950.
Rashid, S., Gulfam, A., Noor, T. A., Yaseen, K., Sheikh, M. A. A., Malik, M., & Malik, J. (2023). Anxiety and depression in heart failure: An updated review. Current Problems in Cardiology, 101987.
Sieske, L., Janssen, G., Babel, N., Westhoff, T. H., Wirth, R., & Pourhassan, M. (2019). Inflammation, appetite and food intake in older hospitalized patients. Nutrients, 11(9), 1986.
Whiteley, L., Olsen, E. M., Haubrick, K. K., Kang, C., Vaughan, I., & Brown, L. K. (2022). A review of digital interventions to decrease cannabis use among patients with comorbid psychiatric disorders. Journal of dual diagnosis, 18(4), 199-210.