IMPACT OF DEPRESSION ON THE IMMUNE SYSTEM OF YOUNG PEOPLE IN ATHENS, GREECE
Abstract
Purpose of the Study: The study sought to investigate the impact of depression on the immune system of young people in Athens, Greece
Statement of the Problem: The impacts of depression on the immune system of young people in Athens, Greece, represent a critical and multifaceted issue. Despite its rich cultural heritage, Athens is grappling with a rising prevalence of depression among its youth, driven by factors such as academic pressure, economic challenges, and evolving societal norms. Understanding how depression influences the immune system in this specific demographic is imperative for developing effective strategies to address both mental and physical well-being in this vulnerable population.
Findings: A significant correlation between depression and compromised immune function among young people in Athens, Greece was noted. Biological mechanisms such as elevated cortisol levels and chronic inflammation were observed in individuals with depression, potentially making them more susceptible to infections and immune-related health issues. The impact of cultural and societal factors, including stigma surrounding mental health and limited access to mental healthcare services, exacerbates the negative effects of depression on the immune system in this population. These findings underscore the urgent need for holistic interventions that address mental health awareness, reduce stigma, and promote healthy lifestyle choices to strengthen the immune system and overall well-being of young Athenians facing depression.
Conclusion: In conclusion, the impacts of depression on the immune system of young people in Athens, Greece, represent a pressing concern with far-reaching implications for both mental and physical health. The study's findings highlight the significant association between depression and compromised immune function, emphasizing the need for comprehensive interventions that address both mental health and immune health. To safeguard the well-being of young Athenians, it is imperative to destigmatize mental health issues, enhance access to mental healthcare services, and promote healthy lifestyles as part of a holistic approach to improve their immune resilience and overall quality of life.
Recommendations: Implement public health campaigns aimed at reducing mental health stigma and increasing awareness about depression's effects on the immune system, targeting both young people and their families in Athens. Establish accessible and youth-friendly mental health services, integrating mental and physical health care, and prioritize the promotion of healthy lifestyles, including exercise, nutrition, and sleep, to bolster immune resilience and improve the overall well-being of young Athenians.
Keywords: Depression, Immune System, Young People, Greece
References
Al-Nasiry, S., Ambrosino, E., Schlaepfer, M., Morré, S. A., Wieten, L., Voncken, J. W., ... & Kramer, B. W. (2020). The interplay between reproductive tract microbiota and immunological system in human reproduction. Frontiers in immunology, 11, 378.
Cacha, L. A., Poznanski, R. R., Latif, A. Z., & Ariff, T. M. (2019). Psychophysiology of chronic stress: An example of mind-body interaction. NeuroQuantology, 17(07), 53-63.
Cai, M., Park, H. R., & Yang, E. J. (2022). Nutraceutical Interventions for Post-Traumatic Stress Disorder in Animal Models: A Focus on the Hypothalamic–Pituitary–Adrenal Axis. Pharmaceuticals, 15(7), 898.
Cañas-González, B., Fernández-Nistal, A., Ramírez, J. M., & Martínez-Fernández, V. (2020). Influence of stress and depression on the immune system in patients evaluated in an anti-aging unit. Frontiers in psychology, 11, 1844.
Foster, J. A., Baker, G. B., & Dursun, S. M. (2021). The relationship between the gut microbiome-immune system-brain axis and major depressive disorder. Frontiers in neurology, 12, 721126.
Gold, S. M., Köhler-Forsberg, O., Moss-Morris, R., Mehnert, A., Miranda, J. J., Bullinger, M., ... & Otte, C. (2020). Comorbid depression in medical diseases. Nature Reviews Disease Primers, 6(1), 69.
Ho, T. C., Teresi, G. I., Segarra, J. R., Ojha, A., Walker, J. C., Gu, M., ... & Gotlib, I. H. (2021). Higher levels of pro-inflammatory cytokines are associated with higher levels of glutamate in the anterior cingulate cortex in depressed adolescents. Frontiers in psychiatry, 12, 642976.
Hui, C. L. M., Wong, S. M. Y., Yu, T. Y. T., Lau, T. T. Y., Choi, O., Tsang, S., ... & Chen, E. Y. H. (2022). Visual-stress-related cortical excitability as a prospective marker for symptoms of depression and anxiety in young people. European Archives of Psychiatry and Clinical Neuroscience, 1-10.
Madireddy, S., & Madireddy, S. (2022). Supportive model for the improvement of mental health and prevention of suicide among LGBTQ+ youth. International Journal of Adolescence and Youth, 27(1), 85-101.
Mattina, G. F., Van Lieshout, R. J., & Steiner, M. (2019). Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events. Therapeutic advances in cardiovascular disease, 13, 1753944719851950.
Peters, E. M., Schedlowski, M., Watzl, C., & Gimsa, U. (2021). To stress or not to stress: Brain-behavior-immune interaction may weaken or promote the immune response to SARS-CoV-2. Neurobiology of stress, 14, 100296.
Ravi, M., Miller, A. H., & Michopoulos, V. (2021). The immunology of stress and the impact of inflammation on the brain and behaviour. BJPsych advances, 27(3), 158-165.
Seiler, A., Von Känel, R., & Slavich, G. M. (2020). The psychobiology of bereavement and health: A conceptual review from the perspective of social signal transduction theory of depression. Frontiers in psychiatry, 11, 565239.
Twenge, J. M., Joiner, T. E., Rogers, M. L., & Martin, G. N. (2018). Increases in depressive symptoms, suicide-related outcomes, and suicide rates among US adolescents after 2010 and links to increased new media screen time. Clinical Psychological Science, 6(1), 3-17.
